Serena Beach Hotel & Spa is situated on Shanzu Beach, the most northerly portion of the coast between Mombasa and Mtwapa Creek, the hotel looks out over the waters of the Mombasa Marine National Park, a 200 square kilometer National Marine Reserve.
Serena Beach Hotel & Spa is 20 km north of central Mombasa along the main Mombasa/Malindi highway.
Moi International Airport, Mombasa (27km from the hotel) whilst there is a small local airstrip at nearby Shanzu.